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Topiramate sprinkle capsules may cause high blood ammonia levels hyperammonemia. This risk may be greater in patients with metabolism problems or certain liver problems. It may also be greater in patients who are taking valproic acid. Contact your doctor immediately if you experience decreased alertness, mental changes, sluggishness, unusual tiredness, or vomiting. Neurontin or topiramate Topamax also treat nerve pain and may ease a painful condition called postherpetic neuralgia that can happen with multiple myeloma. Antipsychotic drugs affect chemicals in the brain called neurotransmitters. It is not clear exactly how these drugs work, but they usually improve manic episodes quickly. can you buy dilantin tablets in australia dilantin

Topiramate adult dosage

Additional nonspecific CNS events commonly observed with topiramate in the add-on epilepsy population include dizziness or ataxia. Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Tablets contain the following inactive ingredients: colloidal silicon dioxide, lactose monohydrate, magnesium stearate, microcrystalline cellulose, partially hydrolyzed polyvinyl alcohol, polyethylene glycol, sodium starch glycolate, talc, titanium dioxide, iron oxide yellow 50 mg and 100 mg only and iron oxide red 50 mg and 200 mg only.

Does topiramate interact with other medications

See your doctor as soon as you can to rule them out. Since topiramate is presumed to undergo significant tubular reabsorption, it is uncertain whether this experience can be generalized to all situations of renal impairment. It is conceivable that some forms of renal disease could differentially affect glomerular filtration rate and tubular reabsorption resulting in a clearance of topiramate not predicted by creatinine clearance. Dosage is based on your medical condition and response to treatment. The prescriber should be aware that these data were obtained when topiramate was added to concurrent antiepileptic drug therapy and cannot be used to predict the frequency of adverse events in the course of usual medical practice where patient characteristics and other factors may differ from those prevailing during clinical studies. Similarly, the cited frequencies cannot be directly compared with data obtained from other clinical investigations involving different treatments, uses, or investigators. Inspection of these frequencies, however, does provide the prescribing physician with a basis to estimate the relative contribution of drug and non-drug factors to the adverse event incidences in the population studied.

It should not be stored for future use

Keep Topiramate Extended-Release Capsules in a tightly closed container. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist. The capsules may either be swallowed whole or opened and sprinkled over a spoonful of soft food, such as applesauce, custard, ice cream, oatmeal, pudding, or yogurt. Do not crush or chew the beads inside the capsule.



Prescribing information for topiramate

The mean plasma elimination half-life is 21 hours after single or multiple doses. Steady state is thus reached in about 4 days in patients with normal renal function. Morphine is one of the most common for multiple myeloma pain. Other opioids include codeine, fentanyl, hydrocodone, hydromorphone, methadone, and oxycodone. These may come in pills, patches, lozenges, or a spray. Patients in these studies were permitted a maximum of two antiepileptic drugs AEDs in addition to topiramate tablets or placebo. In each study, patients were stabilized on optimum dosages of their concomitant AEDs during baseline phase lasting between 4 and 12 weeks. Patients who experienced a prespecified minimum number of partial onset seizures, with or without secondary generalization, during the baseline phase 12 seizures for 12-week baseline, 8 for 8-week baseline or 3 for 4-week baseline were randomly assigned to placebo or a specified dose of topiramate tablets in addition to their other AEDs. Verapamil Calan, Isoptin. Your doctor may call this drug a "calcium channel blocker. Moshé, Solomon L. 2005. Burlington: Elsevier. Your doctor will also probably suggest you drink eight to 12 glasses of water a day during treatment and use a normal amount of salt in your food. This helps to keep your lithium level steady.



Topiramate overdose

Store at room temperature away from light and moisture. not store in the bathroom. Keep all away from children and pets. These dose-related adverse reactions began with a similar frequency in the titration or in the maintenance phase, although in some patients the events began during titration and persisted into the maintenance phase. Some patients who experienced one or more cognitive-related adverse reactions in the titration phase had a dose-related recurrence of these reactions in the maintenance phase. Kudin, AP; Debska-Vielhaber, G; Vielhaber, S; Elger, CE; Kunz, WS 2004. “The mechanism of neuroprotection by topiramate in an animal model of epilepsy”. Epilepsia. Patients may have reported more than one adverse event during the study and can be included in more than one adverse event category. Topiramate is a white to off-white powder. Topiramate is freely soluble in polar organic solvents such as acetonitrile and acetone; and very slightly soluble to practically insoluble in non-polar organic solvents such as hexanes. Topiramate has the molecular formula C 12H 21NO 8S and a molecular weight of 339. So your doctor may not want you to take it if you're pregnant. The prescriber should be aware that these data cannot be used to predict the frequency of adverse events in the course of usual medical practice where patient characteristics and other factors may differ from those prevailing during the clinical study. Similarly, the cited frequencies cannot be directly compared with data obtained from other clinical investigations involving different treatments, uses, or investigators. Inspection of these frequencies, however, does provide the prescribing physician with a basis to estimate the relative contribution of drug and non-drug factors to the adverse event incidences in the population studied. Johnson BA, Rosenthal N, Capece JA, et al. October 2007. The percent reduction in the frequency of partial-onset seizure, baseline period compared to the treatment phase, was the primary endpoint. Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist. Kerr, A. R. Safety and effectiveness of topical dry mouth products containing olive oil, betaine, and xylitol in reducing xerostomia for polypharmacy-induced dry mouth. J Oral Rehabil. clozapine



What should i avoid while taking topiramate

If you start on the first day of your period, you do not need to use back-up birth control the first week. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages. Rarely, blood clots have occurred in patients given topamax. However, it has not been proven that these were caused by this medicine. Rarely, blurring of vision and eye pain have been reported. Buy a pill box for your child with spaces for each dose. You might also want to use alarms -- maybe on a wrist watch, cell phones, or computer -- to remind your child to take his or her medication. Hydrochlorothiazide HCTZ: A drug-drug interaction study conducted in healthy volunteers evaluated the steady-state pharmacokinetics of HCTZ 25 mg q24h and topiramate 96 mg q12h when administered alone and concomitantly. The results of this study indicate that topiramate C max increased by 27% and AUC increased by 29% when HCTZ was added to topiramate. The clinical significance of this change is unknown. The addition of HCTZ to topiramate therapy may require an adjustment of the topiramate dose. The steady-state pharmacokinetics of HCTZ were not significantly influenced by the concomitant administration of topiramate. Clinical laboratory results indicated decreases in serum potassium after topiramate or HCTZ administration, which were greater when HCTZ and topiramate were administered in combination. AUC to either component of the oral contraceptive.



Use of topiramate

Is not administered but is an active metabolite of carbamazepine. Some people who have migraine-related vertigo don't get this symptom until several years after their headache episodes begin. But having a seizure during pregnancy could harm both mother and baby. There may be other seizure medicine that can be more safely used during pregnancy. Tell your doctor right away if you become pregnant while taking topiramate. This information does not take the place of talking to your healthcare provider about your medical condition or treatment. Verapamil cuts down on how many headaches you get. It can take a while to start working. So in the meantime, you may also need to take other preventive medicines that work faster, such as steroids. Patients in these adjunctive trials were receiving 1 to 2 concomitant antiepileptic drugs in addition to topiramate or placebo Values represent the percentage of patients reporting a given reaction. Patient may have reported more than one adverse reaction during the study and can be included in more than one adverse reaction category. dutasteride can i order usa



Reviews for topiramate

In hepatically impaired patients topiramate plasma concentrations may be increased. The mechanism is not well understood. Topiramate sprinkle capsules may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they take topiramate sprinkle capsules. Topiramate can be taken before, during, or after a meal. Topiramate Extended-Release Capsules may be swallowed whole or, if you cannot swallow the capsule whole, you may carefully open the Topiramate Extended-Release Capsule and sprinkle the medicine on a spoonful of soft food like applesauce. Report any new or worsening mood symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive mentally or physically depressed, or have thoughts about suicide or hurting yourself. This medication has rarely caused severe sometimes fatal disease of the . This may occur at any time during treatment and can quickly worsen. MTHFR-deficient male mice is partially alleviated by lifetime dietary betaine supplementation. Tablets can be taken before, during, or after a meal. Drink plenty of fluids during the day. Topamax and death was for overdosing on the medication. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial Neurology. This medicine has been prescribed for you only. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Drugs. Due to an increased risk for problems, people with certain such as Alpers-Huttenlocher syndrome should not use this medication. Children younger than 2 years who might have these disorders should not use this medication. Children older than 2 years who might have these disorders should be closely monitored during treatment with sodium. Talk to your doctor for details. Olthof MR, van Vliet T, Verhoef P, et al. Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans.



Vimpat can be taken with or without food

Following a single oral 100 mg dose, maximum plasma concentration for elderly and young adults was achieved at approximately 1-2 hours. Reflecting the primary renal elimination of topiramate, topiramate plasma and renal clearance were reduced 21% and 19%, respectively, in elderly subjects, compared to young adults. Similarly, topiramate half-life was longer 13% in the elderly. Reduced topiramate clearance resulted in slightly higher maximum plasma concentration 23% and AUC 25% in elderly subjects than observed in young adults. Topiramate clearance is decreased in the elderly only to the extent that renal function is reduced. Metabolic acidosis has been observed at doses as low as 50 mg per day. Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Wilcken DE, Wilcken B, Dudman NP, Tyrrell PA. Homocystinuria - the effects of betaine in the treatment of patients not responsive to pyridoxine. Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for depression or anxiety can add to sleepiness caused by topiramate. Tell your doctor if you regularly use any of these medicines, or any other seizure medication. Triptans can shorten your headache and give you pain relief. Sumatriptan: Multiple dosing of topiramate 100 mg every 12 hrs in 24 healthy volunteers 14 M, 10 F did not affect the pharmacokinetics of single dose sumatriptan either orally 100 mg or subcutaneously 6 mg. Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. WebMD Medical News: "Epilepsy Surgery Works for Many. Corticosteroids steroids. Doctors also call these meds, which include prednisone Rayos, Sterapred “glucocorticoids. If you are taking hormonal such as pills, patch, or ring with this medication, tell your doctor if you have any new spotting or breakthrough bleeding. See a doctor right away. Take the medicine pack with you. SCORES for length, weight, and head circumference compared to age and sex-matched normative data, although these patients are likely to have different growth rates than normal infants. Methylenetetrahydrofolate reductase deficiency with progressive polyneuropathy in an infant. Brain Dev. Letmaier, M; Schreinzer, D; Wolf, R; Kasper, S 2001. "Topiramate as a mood stabilizer". International clinical psychopharmacology. buy aceon plus



How to use topiramate

Dosing in patients 2 to less than 10 years is based on weight. During the titration period, the initial dose of Topiramate Extended-Release Capsules should be 25 mg once daily given at nighttime for the first week. Based upon tolerability, the dosage can be increased to 50 mg once daily in the second week. Dosage can be increased by 25 mg to 50 mg once daily each subsequent week, as tolerated. Titration to the minimum maintenance dose should be attempted over 5 to 7 weeks. Topiramate Extended-Release Capsules may cause eye problems. Tablets therapy, careful attention should be given to the routine monitoring of patients for adequate control of their diabetic disease state. The hyperammonemia associated with topiramate treatment appears to be more common when used concomitantly with VPA. Read the Patient Information Leaflet provided by your before you start using this product and each time you get a refill. The leaflet contains very important information on when to take your pills and what to if you miss a dose. If you have any questions, ask your doctor or pharmacist. Topiramate is excreted in the milk of lactating rats. The excretion of topiramate in human milk has not been evaluated in controlled studies. Limited observations in patients suggest an extensive secretion of topiramate into breast milk. Since many drugs are excreted in human milk, and because the potential for serious adverse reactions in nursing infants to topiramate is unknown, the potential benefit to the mother should be weighed against the potential risk to the infant when considering recommendations regarding nursing. Many epilepsy drugs cause specific side effects, and you should ask your child's doctor about them. Any side effects should be checked out with a doctor. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Kudin, AP; Debska-Vielhaber, G; Vielhaber, S; Elger, CE; Kunz, WS 2004. "The mechanism of neuroprotection by topiramate in an animal model of epilepsy". Epilepsia. These side effects can increase the risk of falling. Values represent the percentage of patients reporting a given adverse event. Patients may have reported more than one adverse event during the study and can be included in more than one adverse event category. Use is not recommended. Topiramate is a CNS depressant. Concomitant administration of topiramate with other CNS depressant drugs or alcohol can result in significant CNS depression. Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk. In published reports of anticonvulsant use during breastfeeding, most women were taking a combination of anticonvulsants.



General information about topiramate

Wilding J, Van Gaal L, Rissanen A, Vercruysse F, Fitchet M; OBES-002 Study Group. A randomized double-blind placebo-controlled study of the long-term efficacy and safety of topiramate in the treatment of obese subjects. Int J Obes Relat Metab Disord. Other medications can affect the removal of from your body, which may affect how zonisamide works. When topiramate replaces another antiepileptic drug, the dose of the other antiepileptic should be reduced gradually at the rate of approximately one-third of the dose every 2 weeks while initiating topiramate therapy. When an enzyme-inducing drug is discontinued, topiramate levels may increase and a decrease in the topiramate dosage may be required. Do not stop taking any medications without consulting your healthcare provider. Consult your doctor before breast-feeding. Zonisamide is a sulfonamide anticonvulsant and a carbonic anhydrase inhibitor. It is unknown how zonisamide works to prevent seizures. You can take the tablets with or without food. At first, 25 or 50 milligrams mg once a day. Your doctor may adjust the dose as needed. However, the dose is usually not more than 400 mg per day. pyrantel



Common side effects of topiramate

Topamax is used during pregnancy. Bloomer, R. J. The effects of chronic betaine supplementation on exercise performance, skeletal muscle oxygen saturation and associated biochemical parameters in resistance trained men. J Strength. Topiramate is not extensively metabolized and is primarily eliminated unchanged in the urine approximately 70% of an administered dose. Six metabolites have been identified in humans, none of which constitutes more than 5% of an administered dose. The metabolites are formed via hydroxylation, hydrolysis, and glucuronidation. There is evidence of renal tubular reabsorption of topiramate. In rats, given probenecid to inhibit tubular reabsorption, along with topiramate, a significant increase in renal clearance of topiramate was observed. This interaction has not been evaluated in humans. The FDA approved TopamaxR tablets and TopamaxR sprinkle capsules for the prophylaxis prevention of in adults. The drug is not approved for the treatment of migraine headaches after they occur; what's known as acute treatment. Study 7 was a randomized, double-blind, adjunctive, placebo-controlled, parallel group study with 3 treatment arms: 1 placebo; 2 topiramate 200 mg per day with a 25 mg per day starting dose, increased by 25 mg per day each week for 8 weeks until the 200 mg per day maintenance dose was reached; and 3 topiramate 200 mg per day with a 50 mg per day starting dose, increased by 50 mg per day each week for 4 weeks until the 200 mg per day maintenance dose was reached. All patients were maintained on concomitant carbamazepine with or without another concomitant antiepileptic drug. Warn patients about the possible development of hyperammonemia with or without encephalopathy. Berlant JL, Van Kammen DP. Open label topiramate as primary or adjunctive therapy in chronic civilian posttraumatic stress disorder: a preliminary report. J Clin Psychiatry. Peripheral Nervous System Disorders: Infrequent: neuropathy, apraxia, hyperaesthesia, dyskinesia, dysphonia, scotoma, ptosis, dystonia, visual field defect, encephalopathy, EEG abnormal. Rare: upper motor neuron lesion, cerebellar syndrome, tongue paralysis. As in the general population, the incidence of stone formation among topiramate-treated patients was higher in men. Kidney stones have also been reported in pediatric patients taking topiramate for epilepsy. Take Topiramate tablets exactly as prescribed. For the monotherapy epilepsy population in the 50 mg per day and 400 mg per day groups, the incidence of somnolence was dose-related 9% for the 50 mg per day group and 15% for the 400 mg per day group and the incidence of fatigue was comparable in both treatment groups 14% each. For other uses not approved for Topiramate Extended-Release Capsules, somnolence and fatigue were more common in the titration phase. Topamax has been known to trigger severe nearsightedness along with increased pressure inside the eye.



You want relief -- now

If you're having pain, you don't have to just live with it. Work with your doctor and explore ways to treat it. Which Drugs Can Treat My Multiple Myeloma Pain? After titration, patients entered a 12-week stabilization period. TMS may short-circuit a migraine by turning on your brain in a particular way. When you feel a headache coming, hold a small device that releases a pulse of magnetic energy on the back of your head for about a minute. You'll need a prescription for this gadget, too. Schumann, H. Contact dermatitis due to use of Octenisept in wound care. J Dtsch. The multidisciplinary evaluation is directed by a neurologist specializing in epilepsy an epileptologist. A patient's eligibility for surgery is determined jointly by the neurosurgeon, neuroradiologist, neuropsychologist, social worker, and epileptologist. The decision to have the surgery is made jointly by the patient and the epileptologist after carefully reviewing the risks and benefits of the procedure. Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, antihistamines such as cetirizine, diphenhydramine drugs for sleep or anxiety such as alprazolam, zolpidem muscle relaxants such as carisoprodol, cyclobenzaprine and narcotic pain relievers such as codeine, hydrocodone. Hoopes SP, Reimherr FW, Hedges DW, Rosenthal NR, Kamin M, Karim R, Capece JA, Karvois D. Treatment of bulimia nervosa with topiramate in a randomized, double-blind, placebo-controlled trial, part 1: improvement in binge and purge measures. J Clin Psychiatry. Annals of General Psychiatry. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Topiramate Extended-Release Capsules and other medicines may affect each other causing side effects. nifedipine where to buy uk



How should I take Topiragen topiramate?

Effects on thinking and alertness. Topiramate Extended-Release Capsules may affect how you think, and cause confusion, problems with concentration, attention, memory, or speech. Topiramate Extended-Release Capsules may cause depression or mood problems, tiredness, and sleepiness. Most triptans are pills. Some come as nasal sprays. You get others as shots. Your doctor can show you how to do this at home. The dosage is based on your medical condition and response to treatment. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. If you have any problems, talk to your doctor about your options. This confusion typically lasts for only a short period of time. ECT is given up to three times a week usually for 2 to 4 weeks or sometimes longer. Contact your doctor if your seizures get worse or you have them more often while taking topiramate. To be sure this medication is not causing harmful effects, your blood may need to be tested often. Your kidney or liver function may also need to be tested. Visit your doctor regularly. Tuma, D. J. The effect of betaine in reversing alcoholic steatosis. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use. You should avoid drinking when taking topiramate. American Epilepsy Society web site.



Topiramate ingredients

Betaine anhydrous prevents the buildup of homocysteine seen in people who have problems with its from birth. Topiramate Extended-Release Capsules are indicated as initial monotherapy in patients 2 years of age and older with partial onset or primary generalized tonic-clonic seizures and adjunctive therapy in patients 2 years of age and older with partial onset or primary generalized tonic-clonic seizures. Drink extra water with topiramate to help prevent kidney stones. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased. You may need to stop this medication for a time or take special precautions. The effect of topiramate on labor and delivery in humans is unknown. Glauser, TA; Clark, PO; Strawsburg, R 1998. "A pilot study of topiramate in the treatment of infantile spasms". Epilepsia. More evidence is needed to rate the effectiveness of betaine anhydrous for these uses. Your doctor will also likely prescribe a mood stabilizer, also called an “antimanic” medication. Topiramate may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. It is not possible to know whether this mortality rate is related to immediate-release topiramate treatment, because the background mortality rate for a similar, significantly refractory, young pediatric population 1 month to 24 months with partial epilepsy is not known. Safety risks from ECT are related mainly to the risks of general anesthesia. Some people with certain heart problems shouldn't get ECT or may need especially close monitoring. Topiramate was the probable cause of the diarrhea in the infant. lamisil order now pharmacy europe



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Topiramate dosing information


List of topiramate side effects

Wendel, U. Psychotic symptoms in severe MTHFR deficiency and their successful treatment with betaine. Eur. Patients in Study 8 were permitted a maximum of two antiepileptic drugs AEDs in addition to topiramate tablets or placebo. In Study 8, patients were stabilized on optimum dosages of their concomitant AEDs during an 8-week baseline phase. Patients who experienced at least six partial onset seizures, with or without secondarily generalized seizures, during the baseline phase were randomly assigned to placebo or topiramate in addition to their other AEDs. Tablets may cause eye problems. asato.info sinequan

For Medication Guides, please visit www

Antidepressants. Some of these drugs, such as amitriptyline, nortriptyline, and duloxetine Cymbalta can help treat nerve pain, called neuropathy, that may happen in multiple myeloma. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Vimpat only for the indication prescribed. Do not change your dose without checking with your doctor. What is topiramate Topamax? Tablets. If you would like more information, talk to your healthcare provider.

Sex hormones and their modulators"

La'inez MJ, Pascual J, Pascual AM, Santonja JM, Ponz A, Salvador A. Topiramate in the prophylactic treatment of cluster headache. Headache. Ask your pharmacist about using those products safely. Overdoses of topiramate resulted in signs and symptoms which included convulsions, drowsiness, speech disturbance, blurred vision, diplopia, mentation impaired, lethargy, abnormal coordination, stupor, hypotension, abdominal pain, agitation, dizziness and depression. The clinical consequences were not severe in most cases, but deaths have been reported after polydrug overdoses involving topiramate. crestor

Before taking topiramate

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Relevant published information was not found as of the revision date. It is very important to continue taking this medication exactly as prescribed by your doctor.

Severe sometimes fatal brain disorder encephalopathy has rarely occurred, particularly in patients with certain metabolic disorders urea cycle disorders. Ohman I, Vitols S, Luef G et al. Topiramate kinetics during delivery, lactation, and in the neonate: preliminary observations. Epilepsia. These could be signs of a serious condition.

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